Regional anatomy of the pedunculopontine nucleus: Relevance for deep brain stimulation
Identifieur interne : 000F43 ( Main/Exploration ); précédent : 000F42; suivant : 000F44Regional anatomy of the pedunculopontine nucleus: Relevance for deep brain stimulation
Auteurs : Marie-Pierre Fournier-Gosselin [Canada] ; Nir Lipsman [Canada] ; Jean A. Saint-Cyr [Canada] ; Clement Hamani [Canada] ; Andres M. Lozano [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2013-09.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Neural Pathways, Pedunculopontine Tegmental Nucleus.
- methods : Deep Brain Stimulation.
- physiology : Functional Laterality, Neural Pathways, Pedunculopontine Tegmental Nucleus.
- therapy : Parkinson Disease.
- Humans.
Abstract
The pedunculopontine nucleus (PPN) is currently being investigated as a potential deep brain stimulation target to improve gait and posture in Parkinson's disease. This review examines the complex anatomy of the PPN region and suggests a functional mapping of the surrounding nuclei and fiber tracts that may serve as a guide to a more accurate placement of electrodes while avoiding potentially adverse effects. The relationships of the PPN were examined in different human brain atlases. Schematic representations of those structures in the vicinity of the PPN were generated and correlated with their potential stimulation effects. By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy. © 2013 International Parkinson and Movement Disorder Society
Url:
DOI: 10.1002/mds.25620
Affiliations:
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Le document en format XML
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This review examines the complex anatomy of the PPN region and suggests a functional mapping of the surrounding nuclei and fiber tracts that may serve as a guide to a more accurate placement of electrodes while avoiding potentially adverse effects. The relationships of the PPN were examined in different human brain atlases. Schematic representations of those structures in the vicinity of the PPN were generated and correlated with their potential stimulation effects. By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy. © 2013 International Parkinson and Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li><li>Québec</li></region><settlement><li>Montréal</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Fournier Osselin, Marie Ierre" sort="Fournier Osselin, Marie Ierre" uniqKey="Fournier Osselin M" first="Marie-Pierre" last="Fournier-Gosselin">Marie-Pierre Fournier-Gosselin</name></region><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Lipsman, Nir" sort="Lipsman, Nir" uniqKey="Lipsman N" first="Nir" last="Lipsman">Nir Lipsman</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Saint Yr, Jean A" sort="Saint Yr, Jean A" uniqKey="Saint Yr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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